Assay Kits, Clia Kits, Devices, DNA Templates, Elisa Kits

peptide SVVYGLR upregulates cell motility and facilitates oral mucosal wound therapeutic

September 16, 2020

gnrlbiotech

Electrostatically certain lanreotide peptide – gold nanoparticle conjugates for enhanced uptake in SSTR2-positive most cancers cells

Lanreotide peptide (LP) has excessive affinity to somatostatin receptors like SSTR2 and is often used within the remedy of neuro-endocrine tumors. The primary goal of this research is to focus on gold nanoparticles (AuNPs) in direction of SSTR2-positive most cancers cells utilizing lanreotide peptide (LP) because the focusing on agent for enhanced tumor uptake and antitumor exercise. pH mediated adjustments within the floor potential of LP and AuNP is used to put together electrostatically certain AuNP-LP complexes.

AuNP-LP complicated formation was demonstrated by UV-Seen spectroscopy, floor potential, dynamic mild scattering (DLS), small angle X-ray scattering and HR-TEM. Confocal microscopy and circulation cytometric research present that AuNP-LP complicated has greater mobile uptake in SSTR2 expressed most cancers cells (MCF-7 and AR42J) than in CHO cells. The improved mobile uptake of LP coated AuNPs result in ~1.5 to 2-fold GSH depletion and enhanced ROS era in MCF-7 cells.

The preferential cytotoxicity of the AuNP-LP complicated in direction of MCF-7 and AR42J cells, as revealed by MTT assay, is according to the elevated mobile uptake. Our research display that LP coated AuNP can be utilized as an efficient platform to selectively goal SSTR2 optimistic most cancers cells for mixture remedy approaches involving gold nanoparticles.

gnrlbiotech
gnrlbiotech


AAP73769-100UG - BICD1 Peptide - N-terminal region
AAP73769-100UG 100ug
EUR 99

BICD2 Peptide
4675P 0.05 mg
EUR 197.7
Description: (CT) BICD2 peptide

BICD2 Peptide
4677P 0.05 mg
EUR 197.7
Description: (IN) BICD2 peptide

BICD2 Peptide
MBS152448-005mg 0.05mg
EUR 175

BICD2 Peptide
MBS152448-5x005mg 5x0.05mg
EUR 770

BICD2 Peptide
MBS152730-005mg 0.05mg
EUR 175

BICD2 Peptide
MBS152730-5x005mg 5x0.05mg
EUR 770

Mast Cell-Degranulating Peptide (MCD Peptide) / Peptide 401
004-04 100 μg
EUR 140.4

BICD2 Peptide - middle region
MBS3244293-01mg 0.1mg
EUR 180

BICD2 Peptide - middle region
MBS3244293-5x01mg 5x0.1mg
EUR 730

Peptide T
057-01 5 mg
EUR 140.4

FGL Peptide
073-36 100 μg
EUR 214.92

APK peptide
076-81 200 μg
EUR 199.8

NEF peptide
076-83 500 μg
EUR 140.4

SHA peptide
076-84 500 μg
EUR 177.12

YSY peptide
076-86 100 μg
EUR 230.04

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)
024-57 200 μg
EUR 86.4

PSTAIR Peptide
070-61 500 μg
EUR 129.6

PGMtide Peptide
040-69 100 μg
EUR 316.44

Adjuvant Peptide
070-05 500 μg
EUR 36.72

Peptide-epsilon
058-22 500 μg
EUR 114.48

Delicious Peptide
070-21 5 mg
EUR 160.92

proSex peptide (20-55)
040-30 100 μg
EUR 355.32

proSex peptide (28-55)
040-31 100 μg
EUR 282.96

proSex peptide (40-55)
040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide
007-60 100 μg
EUR 214.92

Peptide F-9
038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)
021-94 100 μg
EUR 177.12

Peptide Lv (Rat)
008-73 100 μg
EUR 469.8

NGR Peptide 1
025-74 200 μg
EUR 184.68

Anorexigenic Peptide
070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)
029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)
029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)
029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)
029-06 100 μg
EUR 114.48

Bid BH3 peptide
025-87 1 mg
EUR 170.64

AF-16 Peptide
033-44 200 μg
EUR 214.92

Peptide Lv (Human)
008-71 100 μg
EUR 405

Peptide Lv (Mouse)
008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)
029-08 200 μg
EUR 64.8

ExE peptide M3mP6
064-33 200 μg
EUR 244.08

Peptide B (Bovine)
024-56 200 μg
EUR 81

Peptide F (Bovine)
024-58 200 μg
EUR 114.48

PLP Peptide (103-116) (Bovine)
070-14 5 mg
EUR 140.4

FMRF-Like Peptide
047-32 1 mg
EUR 27

Joining Peptide (Rat)
047-91 200 μg
EUR 160.92

Growth Hormone-Releasing Peptide-Related Peptide-1 (fGRP-RP-1) (Frog)
048-80 500 μg
EUR 177.12

Growth Hormone-Releasing Peptide-Related Peptide-2 (fGRP-RP-2) (Frog)
048-81 200 μg
EUR 214.92

Growth Hormone-Releasing Peptide-Related Peptide-3 (fGRP-RP-3) (Frog)
048-82 200 μg
EUR 214.92

Peptide T (4-8)
057-04 500 μg
EUR 64.8

Peptide T (5-8)
057-05 500 μg
EUR 64.8

Vasonatrin Peptide (VNP)
005-47 200 μg
EUR 214.92

Opioid Peptide Library
L-002 58 peptides
EUR 2691.36

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine)
064-01 200 μg
EUR 108

PGMtide Control Peptide
040-70 100 μg
EUR 316.44

Growth Blocking Peptide
046-92 100 μg
EUR 255.96

Neuron Specific Peptide
047-55 200 μg
EUR 140.4

Heparin Binding Peptide
025-47 500 μg
EUR 102.6

Gastrin Related Peptide
027-09 5 mg
EUR 73.44

Obesity Peptide Library
L-003 160 peptides
EUR 7267.32

[D-Ala1]-Peptide T
057-02 5 mg
EUR 282.96

Peptide YY (PYY) (Human)
059-01 200 μg
EUR 119.88

Eledoisin Related Peptide
046-04 5 mg
EUR 58.32

proSex peptide (28-55) - EIA Kit
EK-040-31 96 wells
EUR 603.72

Peptide F 1 (Lobster)
047-62 500 μg
EUR 73.44

Morphine Tolerance Peptide
050-13 1 mg
EUR 102.6

Phosphate Acceptor Peptide
058-24 500 μg
EUR 73.44

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human)
064-07 200 μg
EUR 114.48

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia brasiliana)
047-39 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia brasiliana)
047-40 500 μg
EUR 214.92

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia californica)
047-42 200 μg
EUR 444.96

Peptide II / pro-Histine-Rich Basic Peptide (HRBP) (29-40) (Aplysia californica)
047-43 500 μg
EUR 214.92

FGL Peptide - FAM Labeled
FG-073-36A 1 nmol
EUR 405

FGL Peptide - Cy3 Labeled
FC3-073-36 1 nmol
EUR 672.84

FGL Peptide - Cy5 Labeled
FC5-073-36 1 nmol
EUR 756

Pedal Peptide (Pep) (Aplysia)
047-61 500 μg
EUR 177.12

ExE peptide M3mP6 mutant
064-35 200ug
EUR 234.36

ExE peptide M3mP6 mutant
064-37 200ug
EUR 234.36

FGL Peptide - FITC Labeled
FG-073-36B 1 nmol
EUR 405

AF-16 Peptide - Antibody
H-033-44 100 μl
EUR 336.96

Artificial peptide SVVYGLR upregulates cell motility and facilitates oral mucosal wound therapeutic

Osteopontin-derived SVVYGLR (SV) 7-amino-acid sequence is a multifunctional and artificial SV peptide implicated in angiogenesis, manufacturing of collagen III, and fibroblast differentiation into myofibroblasts. This research investigated the impact of the SV peptide on mucosal wound therapeutic exercise. Regular human-derived gingival fibroblasts (NHGF) and human oral mucosa keratinocytes (HOMK) had been used for in vitro experiments.

As well as, an oral punch wound was ready on the buccal mucosa in male rats aged 11 weeks, and we evaluated the impact of native injection of SV peptide on wound therapeutic. The artificial SV peptide confirmed no affect on the proliferation and adhesion properties of NHGF and HOMK, however it enhanced the cell motility and migration actions. TGF-β1 receptor inhibitor, SB431542 or SB505124, considerably suppressed the SV peptide-induced migration exercise, suggesting an involvement of TGF-β1 receptor activation. Moreover, SV peptide accelerated the therapeutic means of an in vivo oral wound mannequin, in contrast with management teams.

Additional immunohistological staining of wound tissue revealed that a rise in capillary progress and the higher variety of fibroblasts and myofibroblasts that migrated into the wound space would possibly contribute to the facilitation of the therapeutic course of produced by the SV peptide. The SV peptide has helpful results on oral wound therapeutic via enhancement of the sooner section consisting of angiogenesis and reworking with granulation tissue. The artificial SV peptide could be a helpful remedy possibility, significantly for intractable mucosal wounds brought on by trauma or surgical procedure for progressive lesions similar to oral most cancers.

Characterization and Quantitative Willpower of a Various Group of Bacillus subtilis subsp. subtilis NCIB 3610 Antibacterial Peptides

5 antibacterial peptides produced by Bacillus subtilis NCIB 3610 had been purified, quantified, characterised, and recognized within the current research. Cell-free extracts had been subjected to 3 purification protocols using ammonium sulfate or natural solvent precipitation and their mixture, adopted by ion-exchange chromatography, solid-phase extraction, and preparative high-performance liquid chromatography (HPLC).

The mixed ammonium sulfate and natural solvent precipitation extraction protocol introduced the very best outcomes for peptide purification. Within the 5 fractions that introduced antimicrobial exercise, antibacterial peptides had been quantified by the turbidometric technique and by HPLC utilizing nisin for exterior calibration, with the second offering extra correct outcomes. All peptides had been pH- and temperature-resistant and their sensitivity to proteases remedy indicated their proteinic nature.

 The 5 peptides had been subjected to microwave-assisted acid hydrolysis (MAAH) and following derivatization had been analyzed utilizing norleucine as the inner customary, to find out their amino acid content material. The identification of the remoted peptides utilizing the UniProt and PubChem databases indicated that the 4 peptides correspond to UniProt entries of the bacteriocins Subtilosin-A (Q1W152) Subtilosin-SbOX (H6D9P4), Ericin B (Q93GH3), Subtilin (P10946), and the fifth to the non-ribosomal antibacterial lipopeptide surfactin (CID:443592).

The amino acid content material willpower and computational analyses, utilized within the current work on the antimicrobial peptides of B. subtilis, proved an environment friendly screening and quantification technique of bacteriocins that would doubtlessly be utilized in different bacterial strains. The constructed phylogenetic timber heterogeneity noticed throughout the 5 peptides investigated is perhaps indicative of aggressive benefit of the pressure.

Protein INCA1 (INCA1) Antibody
abx029854-80l 80 µl
EUR 250

Protein INCA1 (INCA1) Antibody
abx306704-100g 100 µg
EUR 362.5

Protein INCA1 (INCA1) Antibody
20-abx306704
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  • 20 ug
  • 50 ug
  • 100 ug
  • 200 ug
  • 1 mg

Protein INCA1 (INCA1) Antibody
abx306704-20g 20 µg
EUR 162.5

Protein INCA1 (INCA1) Antibody
abx306704-50g 50 µg
EUR 250

Peptide T
057-01 5 mg
EUR 140.4

Recombinant Mouse Protein INCA1 (Inca1)
MBS1342408-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1125

Recombinant Mouse Protein INCA1 (Inca1)
MBS1342408-002mgEColi 0.02mg(E-Coli)
EUR 740

Recombinant Mouse Protein INCA1 (Inca1)
MBS1342408-002mgYeast 0.02mg(Yeast)
EUR 905

Recombinant Mouse Protein INCA1 (Inca1)
MBS1342408-01mgEColi 0.1mg(E-Coli)
EUR 885

Recombinant Mouse Protein INCA1 (Inca1)
MBS1342408-01mgYeast 0.1mg(Yeast)
EUR 1055

Recombinant Human Protein INCA1 (INCA1)
MBS1351143-002mgBaculovirus 0.02mg(Baculovirus)
EUR 1120

Recombinant Human Protein INCA1 (INCA1)
MBS1351143-002mgEColi 0.02mg(E-Coli)
EUR 745

Recombinant Human Protein INCA1 (INCA1)
MBS1351143-002mgYeast 0.02mg(Yeast)
EUR 910

Recombinant Human Protein INCA1 (INCA1)
MBS1351143-01mgEColi 0.1mg(E-Coli)
EUR 895

Recombinant Human Protein INCA1 (INCA1)
MBS1351143-01mgYeast 0.1mg(Yeast)
EUR 1065

INCA1
CSB-CL605764HU 10 μg plasmid + 200μl Glycerol Ask for price

INCA Peptide
42-270P 0.1 mg
EUR 405.6
Description: (CT) INCA Peptide

FGL Peptide
073-36 100 μg
EUR 214.92

APK peptide
076-81 200 μg
EUR 199.8

NEF peptide
076-83 500 μg
EUR 140.4

SHA peptide
076-84 500 μg
EUR 177.12

YSY peptide
076-86 100 μg
EUR 230.04

Peptide E / 3200-Dalton Adrenal Enkephalin-Containing Peptide (Bovine)
024-57 200 μg
EUR 86.4

PSTAIR Peptide
070-61 500 μg
EUR 129.6

PGMtide Peptide
040-69 100 μg
EUR 316.44

Adjuvant Peptide
070-05 500 μg
EUR 36.72

Peptide-epsilon
058-22 500 μg
EUR 114.48

Delicious Peptide
070-21 5 mg
EUR 160.92

proSex peptide (20-55)
040-30 100 μg
EUR 355.32

proSex peptide (28-55)
040-31 100 μg
EUR 282.96

proSex peptide (40-55)
040-32 100 μg
EUR 214.92

Bombinin-Like Peptide 1 amide / prepro-Bombinin-Like Peptide (44-70) amide / prepro-Bombinin-Like Peptide (107-133) amide
007-60 100 μg
EUR 214.92

Peptide F-9
038-06 200 μg
EUR 58.32

Sturgeon Peptide (137-158)
021-94 100 μg
EUR 177.12

NGR Peptide 1
025-74 200 μg
EUR 184.68

Peptide Lv (Rat)
008-73 100 μg
EUR 469.8

Human Protein INCA1 (INCA1) ELISA Kit
abx528370-96tests 96 tests
EUR 687.5

Mouse Protein INCA1 (INCA1) ELISA Kit
abx528371-96tests 96 tests
EUR 687.5

Mouse Protein INCA1, Inca1 ELISA KIT
ELI-27217m 96 Tests
EUR 1038

Human Protein INCA1, INCA1 ELISA KIT
ELI-12532h 96 Tests
EUR 988.8

Anorexigenic Peptide
070-10 5 mg
EUR 86.4

GnRH Associated Peptide (GAP) (1-13) / GnRH Precursor Peptide (14-26) (Human)
029-03 500 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-24) / GnRH Precursor Peptide (14-37) (Human)
029-04 100 μg
EUR 114.48

GnRH Associated Peptide (GAP) (1-53) / GnRH Precursor Peptide (14-66) (Human)
029-05 20 μg
EUR 267.84

GnRH Associated Peptide (GAP) (25-53) / GnRH Precursor Peptide (38-66) (Human)
029-06 100 μg
EUR 114.48

Bid BH3 peptide
025-87 1 mg
EUR 170.64

AF-16 Peptide
033-44 200 μg
EUR 214.92

Peptide Lv (Human)
008-71 100 μg
EUR 405

Peptide Lv (Mouse)
008-72 100 μg
EUR 469.8

GnRH Associated Peptide (GAP) (1-13) / Gn-RH Precursor Peptide (14-26) (Rat)
029-08 200 μg
EUR 64.8

ExE peptide M3mP6
064-33 200 μg
EUR 244.08

Peptide B (Bovine)
024-56 200 μg
EUR 81

Peptide F (Bovine)
024-58 200 μg
EUR 114.48

PLP Peptide (103-116) (Bovine)
070-14 5 mg
EUR 140.4

FMRF-Like Peptide
047-32 1 mg
EUR 27

Joining Peptide (Rat)
047-91 200 μg
EUR 160.92

Growth Hormone-Releasing Peptide-Related Peptide-1 (fGRP-RP-1) (Frog)
048-80 500 μg
EUR 177.12

Growth Hormone-Releasing Peptide-Related Peptide-2 (fGRP-RP-2) (Frog)
048-81 200 μg
EUR 214.92

Growth Hormone-Releasing Peptide-Related Peptide-3 (fGRP-RP-3) (Frog)
048-82 200 μg
EUR 214.92

Peptide T (4-8)
057-04 500 μg
EUR 64.8

Peptide T (5-8)
057-05 500 μg
EUR 64.8

Vasonatrin Peptide (VNP)
005-47 200 μg
EUR 214.92

Opioid Peptide Library
L-002 58 peptides
EUR 2691.36

Peptide Histidine Isoleucine 27 (PHI-27) / Porcine Intestinal Peptide (Porcine)
064-01 200 μg
EUR 108

PGMtide Control Peptide
040-70 100 μg
EUR 316.44

Growth Blocking Peptide
046-92 100 μg
EUR 255.96

Neuron Specific Peptide
047-55 200 μg
EUR 140.4

Heparin Binding Peptide
025-47 500 μg
EUR 102.6

Gastrin Related Peptide
027-09 5 mg
EUR 73.44

Obesity Peptide Library
L-003 160 peptides
EUR 7267.32

[D-Ala1]-Peptide T
057-02 5 mg
EUR 282.96

Peptide YY (PYY) (Human)
059-01 200 μg
EUR 119.88

Eledoisin Related Peptide
046-04 5 mg
EUR 58.32

proSex peptide (28-55) - EIA Kit
EK-040-31 96 wells
EUR 603.72

Peptide F 1 (Lobster)
047-62 500 μg
EUR 73.44

Phosphate Acceptor Peptide
058-24 500 μg
EUR 73.44

Morphine Tolerance Peptide
050-13 1 mg
EUR 102.6

Peptide Histidine Methionine 27 (PHM-27) / Peptide Histidine Isoleucine (PHI) (Human)
064-07 200 μg
EUR 114.48

Peptide I / pro-Histine-Rich Basic Peptide (HRBP) (1-26) (Aplysia brasiliana)
047-39 200 μg
EUR 444.96
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